Benzoyl peroxide and vitamin A acid

Question: Topical acne treatment such as benzoyl peroxide (BP) and vitamin A acid. Can we apply to the acne with both of them together.
Answer: BP and topical vitamin A acid are the drug that doctors and pharmacists are often recommended for the treatment of acne. Which should be precaution :  Don't use benzoyl peroxide and vitamin A acid at the same time and same area. Because benzoyl peroxide makes vitamin A acid inactive. So we need to apply benzoyl peroxide in the morning or the afternoon. And apply vitamin A acid before bed.

If using BP or vitamin A acid already. Be careful when using fruit acids(alpha hydorxy acid). Because these drugs are likely to cause skin irritation. If used together, they increase the risk of skin irritation.

The use of vitamin A acid should start with a low concentration. Then gradually, concentration increases.
 In addition, some acne patients, at the beginning of the use of vitamin A acid, should use the low concentration. May also have to apply every other day until skin is familiar, then once every day.
Normally this medication in the form of a topical gel or solution causes skin irritation easily than in the form of cream.